Friday, May 29, 2015

Adverse reactions of commonly prescribed medications to FQ Toxicity patients

Always report adverse reactions:


Health Canada: 1-866-234-2345

Many victims of Fluoroquinolone Toxcity (FQT) are given medications after being floxed. many of which do further harm to a floxed patient . We have compiled a list of common medications a FQT victim may be prescribed and their respective warnings.

This list is provided by the Quinolone Vigilance Foundation as a resource and should neither be construed as medical advice nor as an endorsement for or against the use of medications. Talk to your doctor about your concerns regarding side effects. In no way are we advising patients whether or not to take these, or any, medications. Please note that this list is not complete and many other medications may be prescribed. We encourage everyone to research any medication they are prescribed, and to do the same if you decide to use alternative treatments and/or remedies.

If you believe that other medications should be added to this list or if you would like us to add the adverse event reporting system for your geographic area, please alert us to it at

Lyrica (pregabalin)- Pain, dry mouth, edema, constipation, hypoglycemia, dizziness, ataxia, confusion, abnormal thinking (primarily consists of events related to difficulty with concentration/attention but also includes events related to cognition and language problems and slowed thinking), tremors, abnormal vision, anxiety, headaches, myasthenia gravis, weight gain, arthralgia, depression, suicidal ideation.

Cymbalta (duloxetine)- depression, anxiety, fibromyalgia, nausea, fatigue, decreased appetite, headache, insomnia, palpitations, blurred vision, abdominal pain, suicidal ideation.

Neurontin (gabapentin)- headache, dry mouth, constipation, edema, abnormal thinking (primarily consists of events related to difficulty with concentration/attention but also includes events related to cognition and language problems and slowed thinking), amnesia, fatigue, tremors, anxiety, depression, decreased white blood cell count, impotence, palpitations, pulmonary embolus, pericardial effusion, pericarditis, ovarian failure, bruising, increased bleeding, tendinitis, joint swelling, nerve palsy, aphasia, hallucinations, depersonalization, suicidal ideation.

Ambien (zolpidem)- headache, nausea, depression, vertigo, dry mouth, lethargy, abnormal dreams, hypotension, restless leg syndrome, tachycardia, leg cramps, suicidal ideation, decreased cognition, neurosis, sleep activity (includes sleep walking, sleep shopping, etc), depersonalization, intestinal obstruction, photosensitivity.

Hydrocodone- drowsiness, lethargy, anxiety, dysphoria, dependence, urinary retention, hearing impairment, respiratory depression, mood changes.

It should be noted that acetaminophen is an ingredient in hydrocodone pain medications. Acetaminophen is the active ingredient in Tylenol and Tylenol has its own set of adverse reactions: nausea, stomach pain, loss of appetite, itching, rash, headache, dark urine, clay-colored stools, or jaundice (yellowing of skin or eyes).

Oxycodone- respiratory depression, apnea, respiratory arrest, and (to an even lesser degree) circulatory depression, hypotension, shock, constipation, nausea, dizziness, vomiting, pruritus, headache, dry mouth, sweating, asthenia, insomnia, anxiety, chills, twitching, gastritis, abnormal dreams, edema, depression, seizures, speech disorder, urinary retention, abnormal vision, taste perversion, impotence.

Coumadin (warfarin)- severe bleeding, pain, swelling, headache, dizziness, weakness, taste perversion, hair loss, fatigue, loss of appetite, jaundice.

Flexeril (Cyclobenzaprine)- drowsiness, dry mouth, fatigue, constipation, irregular heartbeat, confusion, hallucinations, depression, tinnitus, unusual dreams, jaundice.

Lexapro (Escitalopram)- mood swings, headache, fatigue, insomnia, hallucinations, overactive reflexes, muscle rigidity, nausea, memory loss, seizures, suicidal ideation.

Prozac (fluoxetine)- restlessness, chills or fever, joint and muscle pain, seizures, confusion, dry mouth, irregular heartbeat, headaches, tremors, blindness, vision changes, depression, eye pain, edema, loss of appetite, weight gain, insomnia, suicidal ideation, jaundice.

Effexor (venlafaxine)- serotonin syndrome (a potentially life-threatening drug reaction that causes the body to have too much serotonin, a chemical produced by the nerve cells), neuroleptic malignant syndrome (a life-threatening brain disorder), agitation, hallucinations, coma, fast heartbeat, changes in blood pressure, increased body temperature, lack of coordination, overactive reflexes, nausea, vomiting, diarrhea, hyponatremia (low blood sodium levels), headache, difficulty concentrating, confusion, weakness, unsteadiness, hallucinations, falls, increased bleeding risk, seizures, suicidal ideation.

Paxil (paroxetine)- suicidal ideation, anxiety, insomnia, impulse issues, headache, nausea, fatigue, dry mouth, seizures, tremor, irregular heartbeat, seratonin toxicity, muscle weakness,

Zoloft (sertraline) – insomnia, dry mouth, nausea, weakness, anxiety, hair loss, muscle pain, abnormal liver function tests, kidney disease, decreased blood platelets, diabetes, liver failure, vasculitis, difficulty swallowing, blood hemorrhage, numbness, tooth decay, suicidal ideation.

Ativan (lorazepam)- drowsiness, dizziness, muscle weakness, headache, blurred vision, insomnia, loss of balance or coordination, forgetfulness, difficulty concentrating, nausea, vomiting, constipation, changes in appetite, confusion, depression, hyperactivity, hallucinations, vertigo, muscle weakness, loss of balance or coordination, insomnia, amnesia, nausea, vomiting, jaundice, suicidal ideation.

Xanax (alprazolam)- depression, drowsiness, difficulty with coordination, fatigue, aphasia, insomnia, blurred vision, abdominal pain, dry mouth, headache, joint pain, irregular heartbeat, muscle weakness, memory loss, hallucinations, joint swelling, jaundice, numbness in hands, feet, and around mouth, suicidal ideation, insomnia, decreased libido.

Zofran (ondansetron)- confusion, dizziness, irregular heartbeat, convulsions, dry mouth, mood changes, cardiac arrest, anxiety,

Non-steroidal anti-inflammatories, aka NSAIDS (Prostaglandins) include:
Aspirin (acetylsalicylic acid)
Celebrex (celecoxib)
Voltaren (diclofenac)
Motrin/Advil (ibuprofen)
Indocin (indomethacin)
Anaprox/Aleve/Naprosyn (naproxen)

nausea, vomiting, constipation, headache, fatigue, gastric problems.

Steroids include Prednisone, hydrocortisone, cortisone.

glaucoma, edema, increased blood pressure, weight gain, cataracts, osteoporosis.

*Please note that in addition to adverse reactions of their own, NSAIDs/Steroids are contraindicated with fluoroquinolone antibiotics and they amplify the toxic effects of fluoroquinolones.

*Another note: Several of the medications listed above cause suicidal ideation. A comprehensive list of suicide hotlines can be found here:


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